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Comparative toxicity of selenium from seleno-DL-methionine, sodium selenate, and Astragalus bisulcatus in pigs

Panter, K.E. and Hartley, W.J. and James, L.F. and Mayland, H.F. and Stegelmeier, B.L. and Kechele, P.O. (1996) Comparative toxicity of selenium from seleno-DL-methionine, sodium selenate, and Astragalus bisulcatus in pigs. Fundamental and Applied Technology. 32:217-223.

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Selenium is an essential micronutrient, although ingestion in
excess in pigs can cause disease conditions including neurological
dysfunction and chronic skin and hoof lesions. Controlled
feeding trials in growing swine, using the same Se content in
feed sources, resulted in higher concentrations (p 0.05) of Se
in blood and organs of pigs fed seleno-DL-methionine compared
with those receiving Astragalus bisulcatus or sodium selenate.
Clinical signs of Se toxicity including neurological signs of paralysis
were more severe and occurred sooner in the A. bisulcatus
group than in the sodium selenate or seleno-DL-methionine
groups. All five pigs fed A. bisulcatus developed neurological
signs of paralysis, and in four the signs occurred within 5 days
of the start of treatment. Four of five pigs fed sodium selenate
also developed paralysis, but this occurred 4 to 21 days after
treatment began. The fifth pig in the group developed signs of
chronic selenosis. Two of five pigs fed seleno-DL-methionine
developed paralysis on 9 and 24 days, respectively, and the
remaining three developed chronic selenosis. Selenium fed to
pigs in three forms [plant (A. bisulcatus), sodium selenate, or
seleno-DL-methionine] resulted in neurological dysfunction and
lesions of symmetrical poliomyelomalacia. These were most severe
in the A. bisulcatus group, which also had polioencephalomalacia.
Although seleno-m-methionine caused the greater increase
in tissue and blood Se concentrations, this did not correlate
with severity of pathological changes, since animals fed A.
bisulcatus developed more severe and disseminated lesions.

Item Type: Article
NWISRL Publication Number: 0919
Subjects: Animal > Animal health
Mass Import - autoclassified (may be erroneous)
Depositing User: Dan Stieneke
Date Deposited: 20 Nov 2010 21:54
Last Modified: 22 Nov 2016 22:42
Item ID: 667